Research funded by the Consortium for Optimization of the use of Mineral AdmiXtures (COMAX) is focused on the mitigation of alkali-silica reaction (ASR). ASR is a multi-step process wherein reactive silicate aggregates in a concrete dissolve, form gels, and induce expansion and cracking. In the interest of preventing this detrimental reaction, COMAX researchers employ comprehensive characterization both of silicate solids and the alkaline solutions they come into contact with. Results provide a means of rapidly and accurately assessing ASR-susceptibility of reactive aggregates, and tailoring appropriate mitigation strategies by the addition of mineral and chemical admixtures. Outcomes of this work will facilitate the use of lower quality aggregates, the beneficial re-purposing of industrial waste byproducts such as fly ash, and ultimately the improvement in durability and service life of the resulting concrete infrastructure made with such materials.